Champix (Varenicline) works by mimicking the effect of nicotine on the brain and thus reducing cravings and effects that cigarettes can give you i.e. the feeling of satisfaction. It is based on a plant extract and has been found to be effective in helping patients to give up smoking completely. Champix works by blocking nicotine receptors in your brain but at the same time it also stimulates them to engage the same feeling of satisfaction as a cigarette would give. If nicotine is then smoked, it will no longer be able to bind to these receptors and thus over time the craving for nicotine will reduce.  In studies, 44% of Champix users quit smoking during weeks 9 to 12 of treatment (compared to 18% on sugar pill).

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